New Developments in Breast Cancer Research - From Lab to Clinic

BACR – Breast Cancer Conference, Gateshead 25^th –27^th November 2024 – Programme

 

Monday 25^th                               

 

12:00 – 13:00                 Registration (coffee)

 

Introduction

13:00 – 13:15                 Simon Vincent – Breast Cancer Now (Welcome)  

13:15 – 13:45                 Patient advocate speakers - Patricia Fairbrother and Hillary Stobart

 

Advances in treatments for breast cancer

 

13:45 – 14:30                 Thomas Helleday – PARP inhibitors from bench to bedside

14:30 – 15:00                Jean Abraham – emerging treatments for breast cancer

 

15:00 – 15:30                 Karen Blyth – In vivo models for studying breast cancer

 

15:30 – 16:00                 Break

 

Bridging the gaps

16:00 – 16:30                 Anna Campbell – Critical gaps and translation priorities concerning lifestyle for prevention and treatment of breast cancer

16:30 – 17:00                 Val Speirs – Male breast cancer

17:00 – 17:30                 Flash poster presentation (90 seconds each)

                                          

17:30 – 19:00                 Poster presentations and reception

 

19:30 -                              Speakers meal

 

 

Tuesday 26^th

 

Mechanisms of tumourigenesis and metastasis

09:00 – 09:45                 Seth Coffelt – Immune cells as regulators of breast cancer development

09:45 – 10:30                 Damir Vareslija – Epigenetic control of breast cancer brain metastasis

 

10:30 – 10:45                 Heba Sailem - Decoding spatial mTOR signalling reveals a differential role for mTOR in the tumour microenvironment

10:45 – 11:00                 Ashia Wheeler Crawford - The Role of bromodomain and extra terminal (BET) proteins in angiogenesis in triple negative breast cancer.

 

10:30 – 11:00                 Break

 

Mechanisms of chemo resistance

11:00 – 11:30                 Kirsty Sawicka – Mechanisms of chemo resistance

11:30 – 12:00                 Luca Magnani – endocrine resistance and dormancy

12:00 – 12:30                 Flash poster presentations (90 seconds each)

 

12:30 – 14:00                 Lunch and poster presentations

 

Research resources

14:00 – 14:30                 Louise Jones – Tissue banking

14:30 – 15:00                Claude Chelala – Bioinformatics analysis of large data sets

 

15:00 – 15:15                 Nina Moderau - Deconvolution of heterogenous 3D breast cancer spheroid dynamics over 8 days at single-cell resolution for cancer drug screening utilising Oblique plane microscopy (OPM)

15:15 – 15:30                 Rebecca Allsopp - Concurrent mutational assessment of circulating tumour cells and ctDNA to guide therapy in metastatic breast cancer

 

15:30 – 16:00                Break

 

Model systems for studying breast cancer

16:00 – 16:30                 Robert Clarke – 3D models for studying breast cancer metastasis

16:30 – 16:45                 Riba Thomas - Human stem cell models of de novo tumorigenesis for the study of cancer development

 

                                          

Novel treatment strategies and resistance mechanisms

16:45 – 17:00                 Ioanna Mavrommatis - Deconvoluting the intra-tumour heterogeneity and subclonal evolution of CDK4/6 inhibitor resistance in ER+ breast cancer

17:00 – 17:15                 Jiabao Zhou - Combining Anakinra with Paclitaxel and Zoledronic acid reduces metastatic outgrowth of triple-negative breast cancer cells in mouse bone and soft tissues

17:15 – 17: 30                Charlene Kay - ER+/HER2+ Breast Cancer – Can Some Patients be Managed on Endocrine Therapy Alone?

 

Career development session

17:30 – 18:30                

Sankari Nagarajan – University of Manchester

Carolyn Staton –  University of Sheffield

From research Scientist to academic teacher alternative career options

Andrew Reynolds - AstraZeneca, Cambridge, UK

A journey from academia to industry

 

 

 

19:00 -                              Conference dinner

 

Wednesday 27^th

 

Molecular regulation of breast cancer

09:00 – 09:45                 Mohamed Bentires-Alj: Tumour heterogeneity and metastasis resistance.

09:45 – 10:15                 Jo Morris – DNA replication and DNA damage repair in breast cancer

                                           and response to treatment

 

10:15 – 10:30                 Siang Boon Koh - A functional crosstalk between a RAS regulator and mitochondrial resilience in chemo refractory triple-negative breast cancer

10:30 – 10:45                 Bruno Simoes - Anti-progestin therapy targets hallmarks of breast cancer risk through epithelial-stromal remodelling

 

 

10:45 – 11:15                 Break

 

The tumour microenvironment and metastasis

11:15 – 11:45                 Clare Isacke – The role of CAFs in driving metastasis

11:45 – 12:15                 Raza Ali – Understanding the evolving face of immune response

 

12:15 – 12:30                 Ute Jungwirth - How chemotherapy alters the tumour microenvironment in breast cancer

12:30 – 12:45                 Daniele Di Biagio - Adiponectin may regulate integrin avb6-dependent breast cancer growth and metastasis

 

12:45 – 13:15                 Oral and poster prizes (1^st and 2^nd)

 

Packed lunch to take away