Louise Fets

Louise Fets is an MRC Investigator and CRUK Career Establishment Awardee, and has been head of the Drug Transport and Tumour Metabolism Lab at the MRC Laboratory of Medical Sciences since 2019. After specialising in Pharmacology during her undergraduate degree, Louise completed her PhD at the MRC LMB in Cambridge, studying signal transduction and gradient sensing in chemotaxis. For her postdoctoral training, Louise moved to the Francis Crick Institute and switched fields to focus on cancer metabolism, which is where she first became interested in membrane transporters. 
 
Louise’s lab studies the role of membrane transporters in cancer metabolism, and how this intersects with their role in drug accumulation. They are particularly interested in whether tumour heterogeneity can cause drugs accumulate to different extents, both in tumours from different patients and in different regions of the same tumour, and they investigate this using a range of cell biology, molecular biology and mass-spectrometry-based approaches. Their aim is to understand the affect heterogeneous drug accumulation may have on drug response in cancer and whether this may impact the development of resistance. 

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