Computational Biologist

  • Salary in the range of £23,800 - £36,000 per annum, dependent upon experience
  • Job Ref: MI/17/80_2
  • Duration: fixed term until 31 March 2022

About the role:

They are seeking a highly motivated Computational Biologist within the Cancer Precision Medicine Advanced Cancer Cultures Team which is located within the Clinical and Experimental Pharmacology (CEP) Group to conduct cutting edge translational research on preclinical cancer models.  The focus of their research is translational medicine with an emphasis on preclinical therapeutics and precision medicine in breast, lung, and colorectal cancers.

The aim of precision medicine is to guide patient treatment via profiling of individual tumours.  To date, great advances have been made in the characterization and cataloguing of molecular aberrations associated with various cancers, however our ability to translate genomic information into clinical benefit has yielded mixed results.  To complement these molecular analyses, they are generating cell culture models from each patient to functionally interrogate tumour biology, including drug response.  The advent of advanced cell culture techniques offers tremendous promise in efficiently generating patient-relevant preclinical models in a timely manner, such that laboratory results may be fed back into the clinic to potentially affect clinical decisions.

In collaboration with physicians at the Christie Foundation NHS Trust, they are generating a biobank of cultures that faithfully recapitulate the tumours from which they were derived.  The aim of this post is to help molecularly characterize a library of patient-derived cultures from a variety of cancer types, which will be used to functionally interrogate tumour biology with the goal of translating laboratory results into clinical benefit.

About you:

You should have at least a BSc in Computational Biology, Mathematics or related discipline plus significant relevant experience analysing transcriptomics data sets.  Additionally you should have experience writing complex code in at least one of the following: Perl, Python, R, Matlab, C, or C++.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (, an Institute of The University of Manchester (, is a world-leading centre for excellence in cancer research.  The Institute is core funded by Cancer Research UK (, the largest independent cancer research organisation in the world. They are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

They are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK MI Paterson Building) in South Manchester (, one of the largest cancer treatment centres in Europe.  These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

How to apply?

To apply for this position please visit their website:

For any informal enquiries about this post, please contact Kris Frese via email:


Start Date

7th February 2018

Closing Date

11th March 2018