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promote the advance
of all aspects of
cancer research.

Clinical Research Fellow – Carcinoma Unknown Primary (CUP)

Clinical and Experimental Pharmacology - Professor Caroline Dive

  • Funded by Manchester Biomedical Research Centre
  • Salary in the range of £30,302 - £47,647 (dependent upon qualifications and experience)
  • Job Ref: MI/17/18
  • Duration of post: 4 year fixed term contract

An exciting opportunity has arisen for a motivated Clinical Fellow within Prof. Caroline Dive’s Clinical and Experimental Pharmacology Group to conduct cutting edge translational research on Carcinoma of Unknown Primary site (CUP). The successful candidate will test the hypothesis that liquid biomarkers, including but not limited to circulating tumour DNA (ctDNA), circulating tumours cells (CTCs) and tumour educated platelets (TEPs), can be used to detect tissue of origin and molecular subtypes in patients with CUP and to direct therapy. It will also examine whether genetics alone or genetics plus other factors, such as the immune microenvironment of CUPs, play a role in potential tumour responses. The project is intended to lead to peer-reviewed publications and the award of a PhD.

The successful applicant should have an MB, ChB (or equivalent) and hold Membership of the Royal College of Physicians (MRCP) (or equivalent) and wish to undertake a period of full-time training in a cancer relevant field.  

The successful candidate will have full General Medical Council (GMC) registration with license to practice medicine in the UK.

You will have a strong desire to develop into a Clinician Scientist and to see your research translated for patient benefit. 

For any informal enquiries about this post, please contact Prof Caroline Dive PhD, FMedSci, email: Dr Ged Brady PhD, email; or Dr Natalie Cook MBChB, PhD, email:

The Cancer Research UK Manchester Institute is a centre for excellence in cancer research ( They occupy state-of-the-art laboratories and provide exceptional core facilities, including next generation sequencing, mass-spectrometry, advanced imaging, bioinformatics, histology, and flow cytometry.  They are core-funded by Cancer Research UK (, the world’s largest cancer organisation, are an Institute of The University of Manchester (, and are adjacent to The Christie NHS Foundation Trust (, one of the largest cancer treatment centres in Europe.  These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes in a vibrant and dynamic city surrounded by beautiful countryside and with excellent national and international transport links. 

To apply for this position, please visit their website:


For applicants who are unable to download the information from their website, please contact the HR Department on 0161 446 3231, email: to have the information sent by post.


The deadline for receipt of applications is: 5th April 2017

Start Date

13th March 2017

Closing Date

5th April 2017