- Salary in the range of £23,800 - £28,200 (dependent upon experience)
- Job Ref: MI/17/10
- Duration of post: Fixed term until 31 March 2022
A Senior Scientific Officer position is available for 5 years funded by Manchester’s Biomedical Research Centre. The post will be within Professor Caroline Dive’s Clinical and Experimental Pharmacology Group (CEP) to conduct cutting edge translational research on preclinical cancer models. The focus of our research is translational medicine with an emphasis on preclinical therapeutics and the biology of late stage disease.
The aim of precision medicine is to guide patient treatment via profiling of individual tumours. To date, great advances have been made in the characterization and cataloguing of molecular aberrations associated with various cancers, however our ability to translate genomic information into clinical benefit has yielded mixed results. To complement these molecular analyses, we aim to generate preclinical models from each patient to functionally interrogate tumour biology, including drug response. The advent of advanced cell culture techniques offers tremendous promise in efficiently generating patient-relevant preclinical models in a timely manner, such that laboratory results may be fed back into the clinic to potentially affect clinical decisions.
In collaboration with physicians at the Christie Foundation NHS Trust, they are generating a biobank of cultures that faithfully recapitulate the tumours from which they were derived. The aim of this post is to help collect, generate, biobank, and characterize a library of patient-derived cultures from a variety of cancer types. These models will be used to functionally interrogate tumour biology with the goal of translating laboratory results into clinical benefit.
The successful applicant should have a BSc in cell and molecular biology, biomedicine, or a related discipline (or equivalent relevant experience). Additionally they should have extensive cell culture expertise and experience in cancer research would be beneficial.
This post is funded from 1st April 2017. For any informal enquiries about this post, please contact Kris Frese, email: firstname.lastname@example.org.
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. They are adjacent to The Christie NHS Foundation Trust (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
Their aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.
The Institute has outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.
To apply for this position please visit their website: www.cruk.manchester.ac.uk/jobs
The deadline for receipt of applications is: 23rd March 2017
Interviews will take place: 4th April 2017